Characterization of retinal damage in the episcleral vein cauterization rat glaucoma model
نویسندگان
چکیده
منابع مشابه
A rat model of glaucoma induced by episcleral vein ligation.
To establish a reliable animal model of glaucoma, we examined if episcleral vein ligation in rat eyes can induce intraocular pressure (IOP) elevation and concomitant characteristic morphological features of glaucoma. IOP elevation was detected on the next day (30.1+/-4.4 mmHg: operated eyes; 21.0+/-1.8 mmHg: control eyes) and persisted at least 7 months after the procedure (24.5+/-2.3 mmHg: ope...
متن کاملAkt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization.
The Akt serine/threonine kinase mediates pro-survival signalings in retina and was reported to be activated in a response to some retinal and optic nerve injuries. Human and experimental glaucoma induce apoptosis of retinal ganglion cells (RGCs). The purpose of this study is to test whether episcleral vein cauterization (EVC) to chronically elevate intraocular pressures (IOPs) in rats increase ...
متن کاملRetinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model.
PURPOSE To characterize a long-term elevated intraocular pressure (IOP) glaucoma model in the rat with respect to electroretinographic (ERG) changes and the pattern and mechanism of retinal ganglion cell (RGC) death. METHODS; An approximate doubling of IOP was induced in one eye (G) of female Wistar rats (150-180 g) by cautery of 3 episcleral/limbal veins. At intervals over 3 to 4 months, measu...
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Asymptomatic chronic retinal vein occlusion that occurs in chronic simple glaucoma is described. The condition is characterized by marked elevation of retinal vein pressure with collateral vessels and vein loops at the optic disc in cases of central vein occlusion, or retinal veno-venous anastomoses along a horizontal line temporal and nasal to the disc in hemisphere vein occlusion. No patient ...
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The Scope of Corneal Grafting. B. W. Rycroft J...JJAN '.% W' ... Opacification in Perforating Corneal Grafts. A. G. gh *.MEDCAIL Slope of Sides of Corneal Grafts and Recipient Beds. 1. Method of Concordance in the Diagnosis of Strabismus. Joseph I. Pascal ... ... Stereoscopic Vision in Relation to Photo-Interpretation. Alan A. Morgan Histochemical Localization of Alkaline Phosphatase in the Ret...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2006
ISSN: 0014-4835
DOI: 10.1016/j.exer.2005.06.013